Safety considerations when taking Turmeric Curcumin. This supplement is considered safe in lower doses but there are a few things to be aware of when taking this supplement. Here are some tips and resources to help. There are certain conditions that should use caution with Turmeric Curcumin. A history of kidney stones, gallbladder disease, iron deficiencies, or if you are pregnant or breastfeeding. Diabetics should be aware that Curcumin can reduce blood sugars.